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- Klotho protein lowered in elderly hypertension https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161594/
- Regulation of Blood Pressure by Klotho https://grantome.com/grant/NIH/R01-HL102074-01A1
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- Anti-aging Gene Linked To High Blood Pressure https://www.sciencedaily.com/releases/2009/08/090819164331.html
- Emerging Roles of Klotho in Cardiovascular Diseases https://medcraveonline.com/JCCR/emerging-roles-of-klotho-in-cardiovascular-diseases.html]
- Association of Klotho gene polymorphism with hypertension and coronary artery disease https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-018-0971-5
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- The Putative Role of the Antiageing Protein Klotho in Cardiovascular and Renal Disease https://www.hindawi.com/journals/ijhy/2012/757469/
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- Change of serum klotho protein and its relationship with endothelial dysfunction, oxidative stress and arterial aging in essential hypertensive patients https://www.longdom.org/proceedings/change-of-serum-klotho-protein-and-its-relationship-with-endothelial-dysfunction-oxidative-stress-and-arterial-aging-in-essential-45822.html
- Klotho Ameliorates Kidney Injury and Fibrosis and Normalizes Blood Pressure by Targeting the Renin-Angiotensin System https://www.sciencedirect.com/science/article/pii/S0002944015004927
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Effect of Transcutaneous Electrical Stimulation of Nerves on Blood …
Pulse pressure and arterial elasticity | QJM: An International Journal of …
Feb 1, 2002 – … stage before vascular lesions or external symptoms become evident (reviewed in …. The relationship between pulse pressure, the resultant pulsatile flow, … mean blood pressure and aortic stiffness in hypertensive rats.13,14 This …. between the measured and calculated waves is impressive.4 Efforts are
The Conundrum of Arterial Stiffness, Elevated blood pressure, and Aging
The aorta’s function of dampening the pulsatile flow generated by the heart is … Despite the great efforts to control hypertension, the number of subjects with … and nature of this relationship, with evidence supporting a role of arterial stiffness in … The aorta provides elasticity over a physiological perfusing pressure range of …
Aortic stiffness: pathophysiology, clinical implications, and approach to …
May 23, 2014 – Aortic stiffness is described as elastic resistance to deformation,1 and is … The final shape and waveform of aortic blood pressure is … The proximal aorta absorbs the energy of the left ventricular ejection and dampens the pulsatile flow. ….. Aortic pulse-wave velocity and its relationshipto mortality in …
RGS2 Proteins Regulate Blood Pressure
Nov 1, 2010 – The kidney is capable of regulating systemic BP primarily because of its role in hormone release and fluid balance. Although it is clear that the …
Long-Lasting Reduction of Blood Pressure by Electroacupuncture in …
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Zhang, Y J; Wu, S L; Li, H Y; Zhao, Q H; Ning, C H; Zhang, R Y; Yu, J X; Li, W; Chen, S H; Gao, J S2018-01-24Objective: To investigate the impact of blood pressure and age on arterial stiffness in general population. Methods: Participants who took part in 2010, 2012 and 2014 Kailuan health examination were included. Data of brachial ankle pulse wave velocity (baPWV) examination were analyzed. According to the WHO criteria of age, participants were divided into 3 age groups: 18-44 years group ( n= 11 608), 45-59 years group ( n= 12 757), above 60 years group ( n= 5 002). Participants were further divided into hypertension group and non-hypertension group according to the diagnostic criteria for hypertension (2010 Chinese guidelines for the managemengt of hypertension). Multiple linear regression analysis was used to analyze the association between systolic blood pressure (SBP) with baPWV in the total participants and then stratified by age groups. Multivariate logistic regression model was used to analyze the influence of blood pressure on arterial stiffness (baPWV≥1 400 cm/s) of various groups. Results: (1)The baseline characteristics of all participants: 35 350 participants completed 2010, 2012 and 2014 Kailuan examinations and took part in baPWV examination. 2 237 participants without blood pressure measurement values were excluded, 1 569 participants with history of peripheral artery disease were excluded, we also excluded 1 016 participants with history of cardiac-cerebral vascular disease. Data from 29 367 participants were analyzed. The age was (48.0±12.4) years old, 21 305 were males (72.5%). (2) Distribution of baPWV in various age groups: baPWV increased with aging. In non-hypertension population, baPWV in 18-44 years group, 45-59 years group, above 60 years group were as follows: 1 299.3, 1 428.7 and 1 704.6 cm/s, respectively. For hypertension participants, the respective values of baPWV were: 1 498.4, 1 640.7 and 1 921.4 cm/s. BaPWV was significantly higher in hypertension group than non-hypertension group of respective age groups ( P< 0.05).
[Comparison of arterial stiffness in non-hypertensive and … – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/29374939by YJ Zhang – 2018 – Cited by 1 – Related articlesJan 24, 2018 – [Comparison of arterial stiffness in non–hypertensive and hypertensive populationof various age groups]. [Article in Chinese; Abstract available …
Relative Contributions of Arterial Stiffness and Hypertension to …
https://www.ahajournals.org/doi/full/10.1161/JAHA.116.004271by TJ Niiranen – 2016 – Cited by 30 – Related articlesOct 26, 2016 – A substantial proportion of treated hypertensives have high arterial stiffness, … that may support the use of arterial stiffness measurements in both populations. …. group serving as referent (with which the other
Elastin in large artery stiffness and hypertension – NCBI – NIH
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383658/by JE Wagenseil – 2012 – Cited by 213 – Related articlesIncreased arterial stiffness is an important, independent predictor of cardiovascular … Tropoelastinis the soluble, monomeric form of elastin secreted by cells.
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Wagenseil, Jessica E.; Mecham, Robert P.2012-01-01Large artery stiffness, as measured by pulse wave velocity (PWV), is correlated with high blood pressure and may be a causative factor in essential hypertension. The extracellular matrix components, specifically the mix of elastin and collagen in the vessel wall, determine the passive mechanical properties of the large arteries. Elastin is organized into elastic fibers in the wall during arterial development in a complex process that requires spatial and temporal coordination of numerous proteins. The elastic fibers last the lifetime of the organism, but are subject to proteolytic degradation and chemical alterations that change their mechanical properties. This review discusses how alterations in the amount, assembly, organization or chemical properties of the elastic fibers affect arterial stiffness and blood pressure. Strategies for encouraging or reversing alterations to the elastic fibers are addressed. Methods for determining the efficacy of these strategies, by measuring elastin amounts and arterial stiffness, are summarized. Therapies that have a direct effect on arterial stiffness through alterations to the elastic fibers in the wall may be an effective treatment for essential hypertension. PMID:22290157
Measurement of the local aortic stiffness by a non-invasive … – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/21286830by M Collette – 2011 – Cited by 11 – Related articlesFeb 1, 2011 – Recently, a simple method has been proposed for the evaluation of the local aortic stiffness (AoStiff) using a non-invasive bioelectrical …
Non-invasive Vagus Nerve Stimulation Acutely Improves Blood …
https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.848.8by JL Sabino-Carvalho – 2017Non-invasive Vagus Nerve Stimulation Acutely Improves Blood Pressure Control … In active tVNS, electrodes were placed on the tragus of the ear and electrical …
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