EXECUTIVE SUMMARY

Background: The unavailability of promising treatment options with fewer side effects and
complications associated with uncontrolled high blood pressure are compelling
governments to call out to industry to find a better solution.

Individuals with hypertension are estimated to face nearly $2000 higher annual healthcare expenditure compared with their nonhypertensive peers. This trend has been relatively stable over 12 years. Healthcare costs associated with hypertension account for about $131 billion (2014). This warrants intense effort toward development of less costly and more effective hypertension prevention and management products with less side effects.

Some common side effects of high blood pressure medicines include:
Cough
Diarrhea or constipation
Dizziness or lightheadedness
Erection problems
Feeling nervous
Feeling tired, weak, drowsy, or a lack of energy
Headache
Nausea or vomiting
Skin rash
Weight loss or gain without trying

Update on Progress: PressureStim this month launched a pilot clinical study in Brazil with its latest product design. We are working with a team that previously completed on their own a successful pilot similar feasibility study. The PressureStim has completed thousands of bioelectric protein expression studies in it labs and has filed over 500 bioelectric protein expression patent claims. PressureStim via the Schuler exclusive license has issued pioneering U.S. patents dating back to 2004. PressureStim is in discussions for collaboration with independent researchers that have completed over 150 patients with successful results in bioelectric treatment of blood pressure with wrist and ankle stimulation (which we believe followed our patent claims). Our bench top stimulator produced by Mettler Electronics in Anaheim, CA has FDA 510K market clearance for improving blood circulation and other indications of use. With this same OEM ISO and cGMPG certified manufacturing team we have developed a new portable palm sized stimulator with auto sequencing of up 6 bioelectric signals and safety shut off features. We have separately sourced wrist and ankle bands that we are adapting with electrodes and micro stimulators which may be used in future product designs. We have sourced ear lobe electrodes that have already been successfully used in a number of auricular vagus nerve studies.

Expected Advantages Over Other Blood Pressure Control Products – Designed To Intended To (confirmation pending full scale controlled studies)
Combination wrist, ankle and ear lobe stimulation is expected to be superior to wrist alone.
Only known bioelectric blood pressure system with patent pending signals to improve elastic properties of peripheral vascular arteries especially the aorta.
Method combines the best learned from thousands of years of acupuncture research with the new field of bioelectric medicine.
Less side effects than blood pressure control drugs.

Substantially less costly long term than blood pressure control drugs. We claim:
Our pioneering 2005 patent claim 1…
1. A method for modulating blood pressure comprising the steps of:
a. selecting from a storage area one or more waveforms representative of waveforms generated in the body and carried by neurons in the body;
b. transmitting or conducting the selected waveforms to a treatment member in contact with the body; and
c. broadcasting the selected waveforms from the treatment member to a target zone in the body.
Implantable method to regulate blood pressure by means of coded nerve signals
Patent number: 6957106

Abstract: A method and device for modulating blood pressure. The method comprises selecting waveforms from a storage area that are representative of body organ function. The selected waveforms are then transmitted to a treatment member, which is in direct contact with the body, and which then broadcasts the waveforms to a blood pressure regulatory points within the body to modulate blood pressure. A control module is provided for transmission to the treatment member. The control module contains the waveforms which are selected and transmitted to the treatment member, and computer storage can be provided for greater storage capacity and manipulation of the waveforms.

Type: Grant
Filed: February 18, 2004
Date of Patent: October 18, 2005
1. A method for modulating blood pressure in a body, comprising the steps of:
providing a treatment member, said treatment member being adapted to be in communication with the body;
providing a plurality of waveform signals representative of waveform signals generated in the body and carried by neurons in the body, said plurality of waveform signals including first waveform signals operative in the control of blood pressure, said plurality of waveform signals being stored in a storage medium;
selecting from said storage medium said first waveform signals;
transmitting said first waveform to said treatment member; and
broadcasting said first waveform signals from said treatment member directly to a blood pressure regulatory point in the body.

Recent Milestones

• Completed lab pre-clinical bioelectric protein expression studies.
• Tested a variety of electrodes and electro acupunctures needles.
• Sourced ear lob electrodes.
• Developed portable palm size stimulator with 6 auto bioelectrical sequences and safety shut off.
• Developed PressureStim web site.
• Exclusive license to pioneering the Schuler bioelectric blood pressure control patent estate dating back to 2004.
• Filed additional new patents claims for bioelectric protein expression based blood pressure control.
• Met with independent research team in California that has completed 150 patients with success and working to conclude a research and commercialization collaboration. PressureStim believes this team followed our patent claims in their work.
• Launched pilot clinical study in Brazil.

Expected Upcoming Milestones

• Completion of pilot clinical study in Brazil.
• Potential completion of collaboration agreement which IF successful would add 150 successful patients to our clinical study total and additional IP on electrode placement positions.
• Updated enhanced web site.
• Completion of Executive Summary.
• Completion of animation video.
• Completion of slide decks for scientists and investors.